Search
Invitrogen
UCP3 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-24895
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to human UCP-3 sequence (amino acids 254-267) with N-terminal lysine added, conjugated to KLH.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.1 mg/mL
规格
110 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
15mM sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: human and mouse skeletal muscle, mitochondrial extract of rat brown adipose tissue.
The corresponding sequence in rat and mouse UCP3 differ by 4 and 3 amino acids respectively. This antibody exhibits no cross reactivity with UCP1 or UCP2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The uncoupling protein UCP1 (formerly designated UCP) is an integral membrane protein unique to brown adipose tissue mitochondria. UCP1 forms a dimer that acts as a proton channel, which can uncouple oxidative phosphorylation by dissipating the electrochemical potential across the inner mitochondrial membrane. This process induces heat production in brown adipose tissue and is involved in regulation of body temperature and glucose metabolism. UCP2 is a structurally related protein that also uncouples mitochondrial respiration. It is more widely expressed in human and mouse tissues, including white adipose tissue and muscle, than is UCP1. UCP2 is thought to play a role in body weight regulation. An additional UCP family member, UCP3, is highly muscle specific and is possibly involved in the uncoupling of oxidative phosphorylation in skeletal muscle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: mitochondrial uncoupling protein 3; similar to uncoupling protein; solute carrier family 25 member 9; UCP 3; uncoupling protein; uncoupling protein 3 (mitochondrial proton carrier) isoform UCP3_1; uncoupling protein 3 (mitochondrial proton carrier) isoform UCP3_2; uncoupling protein 3 (mitochondrial, proton carrier); Uncoupling protein 3, mitochondrial; unnamed protein product
基因别名: SLC25A9; UCP-3
UniProt ID: (Human) P55916, (Rat) P56499, (Mouse) P56501
Entrez Gene ID: (Human) 7352, (Rat) 25708, (Mouse) 22229
response to superoxide
response to hypoxia
fatty acid metabolic process
response to nutrient
response to cold
response to activity
response to insulin
cellular response to hormone stimulus
response to steroid hormone
response to glucocorticoid
transmembrane transport
positive regulation of cold-induced thermogenesis
lipid hydroperoxide transport
response to fenofibrate
hydrogen ion transmembrane transport
mitochondrial transmembrane transport
adaptive thermogenesis
lipid transport
lipid metabolic process
respiratory gaseous exchange
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
