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May serve as a "flippase" as well as a glucosyltransferase that transfers glucose to ceramide. It Catalyzes; UDP-glucose + Nacylsphingosine = UDP + D-glucosyl-N-acylsphingosine. Ceramide Glycosyltransferase is the first step in the Glycosphingolipid synthesis; first glycosylation step. Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Ceramide glucosyltransferase; ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21; GCS; GLCT-1; Glucosylceramide synthase; Glycosylceramide synthase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:ceramide glycosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase
基因别名: AU043821; C80537; Epcs21; GCS; GlcT-1; GLCT1; UGCG; Ugcgl
UniProt ID: (Human) Q16739, (Rat) Q9R0E0, (Mouse) O88693
Entrez Gene ID: (Human) 7357, (Rat) 83626, (Mouse) 22234