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产品信息
PA5-53160
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2649253
产品详细信息
Immunogen sequence: SALHERGHHT VFLLSEGRDI APSNHYSLQR YPGIFNSTTS DAFLQSKMRN IFSGRLTAIE LFDILDHYTK NCDLMVGNHA LIQGLKKEKF DLLLVDPNDM CGFVIAHLLG VKYAVFSTGL WYPAEVGAPA
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
靶标信息
UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.
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生物信息学
蛋白别名: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; uridine diphosphate glycosyltransferase 8
基因别名: CGT; UGT4; UGT8
UniProt ID: (Human) Q16880
Entrez Gene ID: (Human) 7368
protein localization to paranode region of axon
galactosylceramide biosynthetic process
glycosphingolipid metabolic process
cytoskeleton organization
central nervous system development
peripheral nervous system development
flavonoid biosynthetic process
paranodal junction assembly
neuron projection morphogenesis
flavonoid glucuronidation
