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Abnova
UHRF1 Monoclonal Antibody (3A11)
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产品信息
H00029128-M01J
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3A11
抗原
UHRF1 (NP_037414.1, 694 a.a. approximately 793 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: WNEVLASLKD RPASGSPFQL FLSKVEETFQ CICCQELVFR PITTVCQHNV CKDCLDRSFR AQVFSCPACR YDLGRSYAMQ VNQPLQTVLN QLFPGYGNGR
Cell culture grade monoclonal antibodies are obtained by purifying "hybridoma culture medium" which completely eliminates any contamination of mice. They have high affinity, high purity, and no contamination.
靶标信息
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ac2-121; E3 ubiquitin-protein ligase UHRF1; FLJ21925; Hnp95 Huhrf1; hUHRF1; HuNp95; Inverted CCAAT box-binding protein of 90 kDa; MGC138707; nuclear phosphoprotein 95; Nuclear protein 95; Nuclear zinc finger protein Np95; RING finger protein 106; RING-type E3 ubiquitin transferase UHRF1; Transcription factor ICBP90; ub; Ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like with PHD and ring finger domains 1; Ubiquitin-like-containing PHD and RING finger domains protein 1
基因别名: hNP95; hUHRF1; huNp95; ICBP90; NP95; RNF106; TDRD22; UHRF1
UniProt ID: (Human) Q96T88
Entrez Gene ID: (Human) 29128
core promoter proximal region sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
methyl-CpG binding
ligase activity
nucleosomal histone binding
methylated histone binding
histone binding
identical protein binding
hemi-methylated DNA-binding
ubiquitin protein ligase activity
ubiquitin-protein ligase
negative regulation of transcription from RNA polymerase II promoter
DNA repair
transcription, DNA-templated
cell cycle
cell proliferation
maintenance of DNA methylation
histone monoubiquitination
histone ubiquitination
positive regulation of cellular protein metabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of transcription from RNA polymerase II promoter
protein autoubiquitination
regulation of methylation-dependent chromatin silencing
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
