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Invitrogen
ULBP1 Recombinant Rabbit Monoclonal Antibody (13C8)
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ULBP1 Antibody (MA5-50072) in WB
Western blot analysis of ULBP1 in HeLa whole cell lysate, MCF-7 whole cell lysate, Raji whole cell lysate, HEK293 whole cell lysate using a dilution of 1:1,000. Samples were incubated with ULBP1 monoclonal antibody (Product # MA5-50072). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 28 kDa. Observed band size: 36-50 kDa.
产品信息
MA5-50072
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
13C8
抗原
A synthesized peptide derived from human ULBP1
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALCAN-beta; N2DL-1; NKG2D ligand; NKG2D ligand 1; NKG2D ligand1; Retinoic acid early transcript 1I; UL16-binding protein 1; ULBP; ULBP 1
基因别名: N2DL-1; N2DL1; NKG2DL1; RAET1I; ULBP1
UniProt ID: (Human) Q9BZM6
Entrez Gene ID: (Human) 80329
