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Invitrogen
UNC93B1 Polyclonal Antibody
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产品信息
PA5-83437
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: NYITRMAQKY HEYSHYKEQD GQGMKQRPPR GSHAPY
Highest antigen sequence indentity to the following orthologs: Rat - 86%, Mouse - 86%.
靶标信息
The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hUNC93B1; Protein unc-93 homolog B1; unc-93 related protein; Unc-93B1; unc93 homolog B; unc93 homolog B1
基因别名: IIAE1; Unc-93B1; UNC93; UNC93B; UNC93B1
UniProt ID: (Human) Q9H1C4
Entrez Gene ID: (Human) 81622
