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Invitrogen
UNG Recombinant Rabbit Monoclonal Antibody (K01_4K67)
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产品信息
MA567273
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_4K67
抗原
A synthesized peptide derived from human UNG.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA, 50% glycerol, 150mM NaCl
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The human UNG gene encodes both nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase. These forms are generated by alternative splicing and the use of two differentially regulated promoters, PA and PB. The cDNAs for UNG1 and UNG2 are of similar size (2061 and 2058 bp, respectively) and as a result the corresponding mRNAs are not resolved as two species in gel electrophoresis. Nuclear UNG2 differs from mitochondrial UNG1 in 44 amino acids of the N-terminal sequence that is not necessary for catalytic activity. A major role of the UNG gene products is to repair mutagenic U:G mispairs caused by cytosine deamination. For example, UNG2 removes misincorporated dUMP residues. The level and expression pattern of UNG1 and UNG2 differs between cell and tissue type. Additionally, the expression of UNG is cell cycle regulated. The expression and activity of UNG has been found in general to be higher in proliferating as compared to nonproliferating tissues and cells. UNG1 is a 304 amino acid protein. UNG2 is a 313 amino acid protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp781L1143; UDG; UNG; unnamed protein product; Uracil-DNA glycosylase; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2; uracil-DNA glycosylase nuclear isoform
基因别名: DGU; HIGM4; HIGM5; UDG; UNG; UNG1; UNG15; UNG2
UniProt ID: (Human) P13051, (Mouse) P97931
Entrez Gene ID: (Human) 7374, (Mouse) 22256, (Rat) 304577
damaged DNA binding
uracil DNA N-glycosylase activity
protein binding
hydrolase activity
hydrolase activity, hydrolyzing N-glycosyl compounds
ribosomal small subunit binding
hydrolase activity, acting on glycosyl bonds
uridine nucleosidase activity
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
single strand break repair
DNA repair
base-excision repair
cellular response to DNA damage stimulus
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
negative regulation of apoptotic process
depyrimidination
isotype switching
base-excision repair, AP site formation via deaminated base removal
metabolic process
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