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产品信息
PA5-93221
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 852-952 of human USP15 (NP_0063041)
偶联物
形式
Liquid
浓度
1.53 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806676
产品详细信息
Immunogen sequence: SNHYGGMGGG HYTAFAKNKD DGKWYYFDDS SVSTASEDQI VSKAAYVLFY QRQDTFSGTG FFPLDRETKG ASAATGIPLE SDEDSNDNDN DIENENCMHT N; Positive Samples: 293T, LO2; Cellular Location: Cytoplasm, Nucleus
靶标信息
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deubiquitinating enzyme 15; granule cell antiserum positive 18; MGC131982; MGC149838; MGC74854; Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin thioesterase 15; ubiquitin thiolesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4
基因别名: 4921514G19Rik; AI327321; E430033I05Rik; Gcap18; KIAA0529; UNPH-2; UNPH4; USP15
UniProt ID: (Human) Q9Y4E8, (Mouse) Q8R5H1
Entrez Gene ID: (Human) 9958, (Mouse) 14479
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
transforming growth factor beta receptor binding
protein binding
identical protein binding
SMAD binding
ubiquitinated histone binding
catalytic activity
peptidase activity
cysteine-type peptidase activity
hydrolase activity
thiol-dependent ubiquitinyl hydrolase activity
cysteine protease
ubiquitin-dependent protein catabolic process
transforming growth factor beta receptor signaling pathway
protein deubiquitination
BMP signaling pathway
monoubiquitinated protein deubiquitination
histone H2B conserved C-terminal lysine deubiquitination
pathway-restricted SMAD protein phosphorylation
proteolysis
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
