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Invitrogen
USP8 Polyclonal Antibody
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USP8 Antibody (PA5-27947) in ICC/IF
USP8 Polyclonal Antibody detects USP8 protein at cytoplasm by immunofluorescent analysis. Sample: A549 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: USP8 protein stained by USP8 Polyclonal Antibody (Product # PA5-27947) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
PA5-27947
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human USP8. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: H1299, HCT116.
Predicted reactivity: Rhesus Monkey (95%), Bovine (83%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell energy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structure/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Deubiquitinating enzyme 8; hUBPy; mUBPy; putative deubiquitinating enzyme; Ubiquitin carboxyl-terminal hydrolase 8; Ubiquitin isopeptidase Y; Ubiquitin thioesterase 8; ubiquitin thiolesterase 8; Ubiquitin-specific-processing protease 8
基因别名: AI574262; AW557536; HumORF8; KIAA0055; mKIAA0055; SPG59; UBPY; USP8
UniProt ID: (Human) P40818, (Mouse) Q80U87
Entrez Gene ID: (Human) 9101, (Mouse) 84092
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
SH3 domain binding
cadherin binding involved in cell-cell adhesion
peptidase activity
cysteine-type peptidase activity
hydrolase activity
thiol-dependent ubiquitinyl hydrolase activity
cysteine protease
mitotic cytokinesis
ubiquitin-dependent protein catabolic process
endosome organization
cell proliferation
protein deubiquitination
ERBB2 signaling pathway
protein K63-linked deubiquitination
protein K48-linked deubiquitination
cell-cell adhesion
proteolysis
cell cycle
Ras protein signal transduction
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
