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Invitrogen
USP8 Polyclonal Antibody
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产品信息
PA5-96555
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human USP8 (NP_0051453)
偶联物
形式
Liquid
浓度
1.69 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA LKIFKTAEEC RLDRDEERAY VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPGNIKKAVE EAERLSESLK LRYEEAEVRK KLEEKDRQEE AQRLQQKRQE TGREDGGTLA KGSLENVLDS KDKTQKSNGE KNEKCETKEK GAITAKELYT MMTDKNISLI IMDARRMQDY QDSCILHSLS VPEEAISPGV TASWIEAHLP DDSKDTWKKR GNVEYVVLLD WFSSAKDLQI; Positive Samples: MCF7, THP-1, A-549, H125, Mouse brain, Mouse lung, Rat brain; Cellular Location: Cell membrane, Cytoplasm, Endosome membrane, Nucleus, Peripheral membrane protein
靶标信息
USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell energy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structure/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deubiquitinating enzyme 8; hUBPy; mUBPy; putative deubiquitinating enzyme; Ubiquitin carboxyl-terminal hydrolase 8; Ubiquitin isopeptidase Y; ubiquitin specific protease 8; Ubiquitin thioesterase 8; ubiquitin thiolesterase 8; Ubiquitin-specific-processing protease 8
基因别名: AI574262; AW557536; HumORF8; KIAA0055; mKIAA0055; SPG59; UBPY; USP8
UniProt ID: (Human) P40818, (Mouse) Q80U87
Entrez Gene ID: (Human) 9101, (Rat) 296121, (Mouse) 84092
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
SH3 domain binding
cadherin binding involved in cell-cell adhesion
peptidase activity
cysteine-type peptidase activity
hydrolase activity
thiol-dependent ubiquitinyl hydrolase activity
cysteine protease
mitotic cytokinesis
ubiquitin-dependent protein catabolic process
endosome organization
cell proliferation
protein deubiquitination
ERBB2 signaling pathway
protein K63-linked deubiquitination
protein K48-linked deubiquitination
cell-cell adhesion
Ras protein signal transduction
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
proteolysis
cell cycle
