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Invitrogen
UTRN Polyclonal Antibody
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UTRN Antibody (PA5-143876) in ICC/IF
Immunocytochemistry analysis of UTRN in Caco-2 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum. Samples were then incubated in UTRN Polyclonal antibody (Product # PA5-143876) using a dilution of 5 μg/mL. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize using a fluorescence microscope and filter sets appropriate f... View More
产品信息
PA5-143876
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human Utrophin/UTRN recombinant protein (Position: L1211-K2294).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human Sw620 whole cell, human Caco-2 whole cell, human THP-1 whole cell, mouse lung tissue. ICC/IF: CACO-2 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
The UTRN gene encodes the utrophin protein, which is closely related to dystrophin in structure and function, playing a crucial role in maintaining the integrity of muscle fiber membranes. Located on chromosome 6, utrophin is expressed widely in fetal tissues but is replaced by dystrophin in mature muscle fibers; however, it remains present in adult tissues such as the neuromuscular junction and blood vessels. Utrophin's primary role is to stabilize the cytoskeleton and membrane linkages, forming part of the protein complex responsible for structural support in muscle cells. This protein has garnered significant attention in the context of muscular dystrophies, particularly Duchenne Muscular Dystrophy (DMD), where utrophin upregulation is considered a potential therapeutic strategy to compensate for the lack of functional dystrophin. It helps to ameliorate muscle pathology by mimicking the stabilizing effects of dystrophin, thus preserving muscle function and reducing damage. Research on enhancing utrophin expression is ongoing, aiming to provide an effective treatment modality for DMD and other dystrophin-associated disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DRP-1; Dystrophin-related protein 1; G-utrophin; Utrophin; utrophin short isoform, Up109
基因别名: AA589569; DMDL; DRP; DRP1; UTRN
UniProt ID: (Human) P46939
Entrez Gene ID: (Human) 7402, (Mouse) 22288
