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Invitrogen
UTRN Polyclonal Antibody
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UTRN Antibody (PA5149825) in IHC (P)
Immunohistochemistry analysis of UTRN in paraffin-embedded Human Prostate cancer tissue. Samples were incubated with UTRN Polyclonal (Product # PA5149825) antibody using a dilution of 30 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
产品信息
PA5149825
产品规格
种属反应
Human
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant Utrophin (UTRN) (Met1-Glu252)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The UTRN gene encodes the utrophin protein, which is closely related to dystrophin in structure and function, playing a crucial role in maintaining the integrity of muscle fiber membranes. Located on chromosome 6, utrophin is expressed widely in fetal tissues but is replaced by dystrophin in mature muscle fibers; however, it remains present in adult tissues such as the neuromuscular junction and blood vessels. Utrophin's primary role is to stabilize the cytoskeleton and membrane linkages, forming part of the protein complex responsible for structural support in muscle cells. This protein has garnered significant attention in the context of muscular dystrophies, particularly Duchenne Muscular Dystrophy (DMD), where utrophin upregulation is considered a potential therapeutic strategy to compensate for the lack of functional dystrophin. It helps to ameliorate muscle pathology by mimicking the stabilizing effects of dystrophin, thus preserving muscle function and reducing damage. Research on enhancing utrophin expression is ongoing, aiming to provide an effective treatment modality for DMD and other dystrophin-associated disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DRP-1; Dystrophin-related protein 1; Utrophin
基因别名: DMDL; DRP; DRP1; UTRN
UniProt ID: (Human) P46939
Entrez Gene ID: (Human) 7402
