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Agrisera
UVR8/Ultraviolet-B receptor UVR8 Polyclonal Antibody
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UVR8/Ultraviolet-B receptor UVR8 Antibody (AS22-4716) in WB
Each lane contains 20 µg of Arabidopsis thaliana whole leaf extract of the following genetic backgrounds: 1. Columbia ecotype (UVR 8 wild type) 2. uvr 8-6 mutant 3. uvr 8-6/pro UVR 8:YFP-UVR 8 (described in Bernula et al. 2017) 20 µg/well of total protein extracted from liquid N 2-frozen leaves of adult plants using hot extraction buffer containing 65 m M Tris-HCl, p H 7.8,4 M urea, 5% (w/v) SDS, 100 m M di... View More
产品信息
AS22-4716
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide derived from Arabidopsis thaliana UVR8.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
UVR8 encodes a plant UV-B photoreceptor that is present in both the cytosol and nucleus, with UV-B exposure promoting rapid nuclear accumulation where it can associate with chromatin and regulate UV-B-responsive transcriptional programs. Structurally, UVR8 is an RCC1-like protein dominated by a seven-bladed beta-propeller core that forms a stable homodimer in the absence of UV-B; UV-B perception is intrinsic to the protein (no external chromophore) and is mediated by key tryptophan residues at the dimer interface whose excitation destabilizes a network of cross-dimer salt bridges, driving reversible dimer-to-monomer conversion that initiates signaling. Functionally, monomeric UVR8 engages the E3 ubiquitin ligase COP1 through a critical C-terminal segment to promote expression of UV-protective genes (including regulators such as HY5), supporting acclimation responses such as induction of phenylpropanoid/flavonoid biosynthesis and broader photomorphogenic and stress-tolerance outputs under UV-B irradiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AT5G63860; MGI19.7; MGI19_7; UVB-RESISTANCE 8
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