Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Ubiquilin 1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 10
Ubiquilin 1 Antibody (PA1-759) in IHC (P)
Immunohistochemistry analysis of Ubiquilin showing staining in the nucleus and weak staining in the cytoplasm of paraffin-embedded human brain tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methano... View More
产品信息
PA1-759
应用
建议稀释比
已发表文章
产品规格
种属反应
Hamster,
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: A(2) E S A E S G G P P G A Q D S A A(18)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-759 detects ubiquilin from hamster cells.
PA1-759 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~63 kDa protein representing ubiquilin from CHO cell extract.
PA1-759 immunizing peptide corresponds to amino acids residues 2-18 from mouse ubiquilin.
靶标信息
PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hPLIC-1; PLIC-1; Protein linking IAP with cytoskeleton 1; testicular tissue protein Li 219; ubiquilin 1; Ubiquilin-1
基因别名: 1110046H03Rik; 1810030E05Rik; AU019746; C77538; D13Ertd372e; DA41; DSK2; I79_020705; PLIC-1; PLIC1; UBQLN1; UBQN; XDRP1
UniProt ID: (Human) Q9H3R4, (Mouse) Q8R317
Entrez Gene ID: (Human) 29979, (Mouse) 56085, (Chinese hamster) 100764107
autophagosome assembly
macroautophagy
ER-associated ubiquitin-dependent protein catabolic process
regulation of protein ubiquitination
positive regulation of protein ubiquitination
negative regulation of toll-like receptor 3 signaling pathway
response to endoplasmic reticulum stress
aggrephagy
cellular response to hypoxia
autophagosome maturation
negative regulation of store-operated calcium channel activity
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
regulation of macroautophagy
negative regulation of autophagosome maturation
regulation of autophagosome assembly
