Invitrogen

Urocortin Polyclonal Antibody

1 篇参考文献

查看其他3个Urocortin抗体

问题与答案

问题与答案

问题与答案

抗体检测数据 (2)

Urocortin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Urocortin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Urocortin Antibody (PA5-75189) in IHC (P)

Immunohistochemistry analysis of Urocortin in paraffin-embedded human colorectal carcinoma tissue. Samples were incubated with Urocortin polyclonal antibody (Product # PA5-75189) at a dilution of 1:100.

Urocortin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Urocortin Antibody in Western Blot (WB)

Product Image Gallery

Urocortin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of Urocortin in paraffin-embedded human colorectal carcinoma tissue. Samples were incubated with Urocortin polyclonal antibody (Product # PA5-75189) at a dilution of 1:100.

Urocortin Antibody in Western Blot (WB) — Western blot analysis of Urocortin in Lane 1: HEK293T whole cell lysate, Lane 2: sp2/0 whole cell lysate, Lane 3: PC12 whole cell lysate. Samples were incubated with Urocortin polyclonal antibody (Product # PA5-75189) at a dilution of 1:500.

Immunogen image

Urocortin Polyclonal Antibody

Immunogen Image Urocortin Polyclonal Antibody

产品信息

PA5-75189

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

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免疫组化（石蜡） (IHC (P))

1:50-1:200

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acids 80-124 of Human UCN.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

靶标信息

Urocortin (UCN), a 40 amino acids neuropeptide widely distributed in the central nervous system (CNS), belongs to a family of structurally related peptides including corticotrophin releasing factor (CRF), sauvagine and urotensin I. Urocortin is derived from a larger precursor protein (pro-urocortin, also named corticotensin). Urocortin has biological actions similar to CRF such as stress-related endocrine, autonomic and behavioral responses in mammalian species. It is a potent stimulator of adrenocorticotropic hormone (ACTH) secretion by corticotroph cells from the anterior pituitary in vitro and in vivo.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Corticotensin; prepro-urocortin; Urocortin; urocortin, preproprotein

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基因别名: Mpv17; UCN; Ucn1; UI; UROC

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UniProt ID: (Human) P55089, (Rat) P55090, (Mouse) P81615

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Entrez Gene ID: (Human) 7349, (Rat) 29151, (Mouse) 22226

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neuropeptide hormone activity protein binding corticotropin-releasing hormone activity histone deacetylase inhibitor activity corticotropin-releasing hormone receptor 1 binding corticotropin-releasing hormone receptor 2 binding G-protein coupled receptor binding hormone activity peptide hormone

startle response inflammatory response response to oxidative stress G-protein coupled receptor signaling pathway neuropeptide signaling pathway female pregnancy sensory perception of sound associative learning aerobic respiration negative regulation of gene expression response to auditory stimulus pancreatic juice secretion positive regulation of cell growth positive regulation of cAMP biosynthetic process negative regulation of histone deacetylation neuron projection development negative regulation of appetite response to estradiol positive regulation of interleukin-6 production positive regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation activation of protein kinase A activity social behavior gastric emptying drinking behavior negative regulation of apoptotic process positive regulation of vascular permeability positive regulation of translation positive regulation of DNA replication negative regulation of blood pressure negative regulation of cell size positive regulation of vasodilation positive regulation of transcription from RNA polymerase II promoter negative regulation of hormone secretion response to pain response to glucocorticoid positive regulation of corticotropin secretion regulation of synaptic transmission, glutamatergic positive regulation of cardiac muscle contraction negative regulation of gastric acid secretion negative regulation of necrotic cell death positive regulation of calcium ion import negative regulation of neuron death negative regulation of feeding behavior positive regulation of behavioral fear response positive regulation of protein phosphorylation learning or memory feeding behavior positive regulation of gene expression negative regulation of cell death response to immobilization stress response to starvation negative regulation of catalytic activity prepulse inhibition