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Agrisera
V-ATPase Monoclonal Antibody (7A3)
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产品信息
AS17-4163
产品规格
种属反应
Plant
宿主/亚型
Mouse
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
7A3
抗原
V-ATPase complex from Avena sativa.
偶联物
形式
Liquid
保存液
tissue culture supernatant
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Avena sativa
靶标信息
V-ATPase is a conserved, multi-subunit rotary proton pump that localizes primarily to endomembrane compartments (including endosomes, lysosomes, secretory vesicles, and the Golgi network) and, in specialized cells, is also targeted to the plasma membrane to acidify the extracellular space. It is organized into two coupled sectors: a peripheral, cytosolic V1 domain that catalyzes ATP hydrolysis and a membrane-embedded V0 domain that translocates protons across the membrane; the V1 domain contains a catalytic A3B3 head with additional stalk/regulatory subunits (including C, D, E, F, G, and H) that couple nucleotide turnover to rotation, while the V0 domain comprises the large a subunit and a proteolipid c-ring with additional subunits (including d and e) that form the proton-conducting pathway. By pumping H+ into organelle lumens, V-ATPase establishes the acidic pH and electrochemical gradients required for receptor-mediated endocytosis, protein sorting and trafficking, activation of acid-dependent hydrolases/zymogens, and loading of neurotransmitters into synaptic vesicles; isoform-specific subunit usage contributes to compartment- and cell-type-specific targeting and functions, including osteoclast-mediated acidification at the bone-apposed membrane and regulation of lysosomal acidification linked to neurodegenerative and storage disease phenotypes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: vacuolar ATP synthase subunit A; VHA-A
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