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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • VAMP1/VAMP2 Antibodies

          Invitrogen

          VAMP1/VAMP2 Monoclonal Antibody (540524)

          查看其他3个VAMP1/VAMP2抗体

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          Cite VAMP1/VAMP2 Monoclonal Antibody (540524)

          • 抗体检测数据 (1)
          VAMP1/VAMP2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          VAMP1/VAMP2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 1

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          VAMP1/VAMP2 Antibody (MA5-61608) in WB

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          VAMP1/VAMP2 Antibody in Western Blot (WB)
          VAMP1/VAMP2 Monoclonal Antibody (540524)

          产品信息

          MA5-61608

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          0.2 µg/mL
          -

          免疫组化(石蜡) (IHC (P))

          8-25 µg/mL
          -
          产品规格

          种属反应

          Human, Mouse

          宿主/亚型

          Mouse / IgG1

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          540524

          抗原

          E. coli-derived recombinant human VAMP-1, Met1-Lys96
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Lyophilized

          浓度

          0.5 mg/mL

          纯化类型

          Protein A/G

          保存液

          PBS with trehalose

          内含物

          no preservative

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_3702220

          产品详细信息

          Reconstitute at 0.5 mg/mL in sterile PBS.

          靶标信息

          Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis. VAMP (also know as synaptobrevin) is part of the synaptic vesicle docking and fusion complex and plays a central role in neuroexocytosis. Two VAMP (vesicle-associated membrane protein) isoforms are expressed in the nervous system and are differently distributed among the specialized parts of the tissue. VAMP-1 and -2 are present in all tissues tested, including kidney, adrenal gland, liver, pancreas, thyroid, heart, and smooth muscle. The two isoforms are differentially expressed in various tissues and their level may depend on differentiation. VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy. Evidence for the importance of neuronal VAMPproteins in the physiology of all cells is indicated.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: synaptobrevin 2; synaptobrevin II; Synaptobrevin-1; Synaptobrevin-2; VAMP-1; VAMP-2; vesicle-associated membrane 2; Vesicle-associated membrane protein 1; vesicle-associated membrane protein 1 (synaptobrevin 1); Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2)

          查看更多 收起

          基因别名: lew; SPAX1; Syb-1; Syb-2; SYB1; SYB2; sybII; VAMP-1; VAMP-2; VAMP1; VAMP2

          查看更多 收起

          UniProt ID: (Human) P23763, (Human) P63027, (Mouse) Q62442, (Mouse) P63044

          查看更多 收起

          Entrez Gene ID: (Human) 6843, (Human) 6844, (Mouse) 22317, (Mouse) 22318

          查看更多 收起

          功能
          SNARE binding SNAP receptor activity protein binding calmodulin binding phospholipid binding protein C-terminus binding myosin binding syntaxin-1 binding syntaxin binding protein complex binding identical protein binding protein self-association ion channel binding calcium-dependent protein binding
          参与通路
          exocytosis vesicle fusion vesicle-mediated transport SNARE complex assembly protein complex assembly response to glucose protein transport synaptic vesicle exocytosis calcium ion regulated exocytosis regulation of exocytosis regulation of calcium ion-dependent exocytosis cellular response to insulin stimulus Golgi to plasma membrane protein transport eosinophil degranulation long-term synaptic potentiation regulation of vesicle-mediated transport membrane fusion positive regulation of intracellular protein transport regulation of delayed rectifier potassium channel activity post-Golgi vesicle-mediated transport neurotransmitter secretion glutamate secretion neutrophil degranulation natural killer cell degranulation mucus secretion regulation of histamine secretion by mast cell
          It has to be done as per old AB suggested Products section.
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          性能保障

          只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符,您即可享受免费退换货服务。*

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