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Abnova
VAMP2 Recombinant Rabbit Monoclonal Antibody
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产品信息
RAB01333
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Recombinant protein corresponding to human VAMP2.
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
50mM tris glycine, pH 7.4, with 0.05% BSA, 40% glycerol, 150mM NaCl
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP-2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Synaptobrevin; synaptobrevin 2; Synaptobrevin-2; vamp; VAMP-2; Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2)
基因别名: SYB2; VAMP-2; VAMP2
UniProt ID: (Human) P63027
Entrez Gene ID: (Human) 6844
protein complex assembly
exocytosis
post-Golgi vesicle-mediated transport
vesicle fusion
neurotransmitter secretion
response to glucose
glutamate secretion
protein transport
synaptic vesicle exocytosis
vesicle-mediated transport
calcium ion regulated exocytosis
regulation of exocytosis
cellular response to insulin stimulus
Golgi to plasma membrane protein transport
eosinophil degranulation
neutrophil degranulation
natural killer cell degranulation
long-term synaptic potentiation
regulation of vesicle-mediated transport
membrane fusion
mucus secretion
positive regulation of intracellular protein transport
regulation of delayed rectifier potassium channel activity
regulation of histamine secretion by mast cell
