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Invitrogen
VASN Polyclonal Antibody
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VASN Antibody (PA5-110564) in WB
Western blot analysis of VASN in extracts of various cell lines. Samples were incubated with VASN Polyclonal antibody (Product # PA5-110564) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-110564
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 420-575 of human VASN (NP_612449.2).
偶联物
形式
Liquid
浓度
2.2 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: CHLGTRHHLA CLCPEGFTGL YCESQMGQGT RPSPTPVTPR PPRSLTLGIE PVSPTSLRVG LQRYLQGSSV QLRSLRLTYR NLSGPDKRLV TLRLPASLAE YTVTQLRPNA TYSVCVMPLG PGRVPEGEEA CGEAHTPPAV HSNHAPVTQA REGNLP
靶标信息
The VASN gene encodes the protein vasorin, a type I transmembrane protein involved in cellular signaling, vascular development, and tissue repair. Vasorin is characterized by its expression in various tissues, including vascular endothelial cells and smooth muscle cells, where it functions to modulate cell proliferation and differentiation. It plays a significant role in the regulation of vascular remodeling and homeostasis by interacting with signaling molecules like transforming growth factor-beta (TGF-β), thereby influencing processes such as angiogenesis and wound healing. Vasorin is implicated in inhibiting TGF-β signaling pathways, which are crucial for maintaining vascular integrity and preventing excessive fibrosis during tissue repair. Dysregulation of VASN expression can contribute to pathological conditions, including cardiovascular diseases and cancer, where abnormal vascular remodeling and cell proliferation are evident. Research into vasorin continues to explore its functional mechanisms and potential therapeutic applications in diseases characterized by vascular dysregulation and tissue remodeling.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein slit-like 2; Slit-like 2; Vasorin
基因别名: 2610528G05Rik; Atia; Slitl2; Vasn
UniProt ID: (Mouse) Q9CZT5
Entrez Gene ID: (Mouse) 246154, (Rat) 679921
