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Invitrogen
VAV1 Polyclonal Antibody
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VAV1 Antibody (PA5-81113) in WB
Western Blot using VAV1 Polyclonal Antibody (Product # PA5-81113) at 1:500 dilution. Lane A: K562 Whole Cell Lysate, Lane B: MOLT-4 Whole Cell Lysate, Lane C: Raji Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti- RabbitIgG H&L (DyLight™ 800) at 1:10,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 98 kDa. Observed band size: 90 kDa. (We are unsure of the identity of these extra bands).
产品信息
PA5-81113
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the C-terminus of the Human VAV1
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human VAV1.
靶标信息
The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: oncogene vav; Proto-oncogene vav; unnamed protein product; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav proto-oncogene
基因别名: VAV; VAV1
UniProt ID: (Human) P15498
Entrez Gene ID: (Human) 7409
immune response-regulating cell surface receptor signaling pathway
phagocytosis
immune response
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
small GTPase mediated signal transduction
regulation of cell size
response to xenobiotic stimulus
cell migration
natural killer cell activation
platelet activation
T cell differentiation
neutrophil chemotaxis
T cell costimulation
intracellular signal transduction
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
B cell proliferation
T cell activation
natural killer cell mediated cytotoxicity
positive regulation of cell adhesion
positive regulation of natural killer cell mediated cytotoxicity
vascular endothelial growth factor receptor signaling pathway
regulation of small GTPase mediated signal transduction
positive regulation of protein kinase B signaling
cellular response to xenobiotic stimulus
reactive oxygen species metabolic process
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