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Abnova
VAV1 Monoclonal Antibody (1A6)
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产品信息
H00007409-M02
产品规格
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1A6
抗原
VAV1 (AAH13361, 681 a.a. approximately 790 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
规格
100 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: RGLTELVEFY QQNSLKDCFK SLDTTLQFPF KEPEKRTISR PAVGSTKYFG TAKARYDFCA RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC
靶标信息
The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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