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Invitrogen
VAV1 Monoclonal Antibody (GT557)
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图: 1 / 4
VAV1 Antibody (MA5-31488) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of VAV1 was performed in Jurkat cells fixed in 4% paraformaldehyde at RT for 15 min. Green: VAV1 Monoclonal Antibody (GT557) (Product # MA5-31488) diluted at 1:500. Blue: Fluoroshield with DAPI. Scale bar = 10 µm.
产品信息
MA5-31488
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
GT557
抗原
Recombinant protein encompassing a sequence within the center region of human VAV1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (92%), Rat (92%), Pig (96%), Bovine (96%).
Positive Control: Jurkat, NCI-H929.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: oncogene vav; p95vav; Proto-oncogene vav; unnamed protein product; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav oncogene; vav proto-oncogene
基因别名: VAV; vav-T; VAV1
UniProt ID: (Human) P15498, (Mouse) P27870
Entrez Gene ID: (Human) 7409, (Mouse) 22324
phagocytosis
immune response
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
small GTPase mediated signal transduction
T cell differentiation
neutrophil chemotaxis
regulation of Rho protein signal transduction
intracellular signal transduction
T cell activation
regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of cell adhesion
positive regulation of natural killer cell mediated cytotoxicity
reactive oxygen species metabolic process
immune response-regulating cell surface receptor signaling pathway
regulation of cell size
response to xenobiotic stimulus
cell migration
natural killer cell activation
platelet activation
T cell costimulation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
B cell proliferation
natural killer cell mediated cytotoxicity
vascular endothelial growth factor receptor signaling pathway
regulation of small GTPase mediated signal transduction
positive regulation of protein kinase B signaling
cellular response to xenobiotic stimulus
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