Invitrogen

VEGF Receptor 1/2 Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
VEGF Receptor 1/2 Polyclonal Antibody

产品信息

PA1-16612

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:100-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:250-1:500
-

免疫细胞化学 (ICC/IF)

1:500
-
产品规格

种属反应

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide made to an internal region of the mouse VEGF Receptor 1 protein (between residues 800-900).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

4°C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_568765

产品详细信息

The target sequence has 100% sequence homology with mouse and rat.

靶标信息

Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD309; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); FLT; FLT-1; FMS-like tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); KDR; kinase insert domain protein receptor; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Protein-tyrosine kinase receptor flk-1; soluble VEGFR 1; soluble VEGFR2; sVEGFR 1; tyrosine kinase growth factor receptor; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor-1; Vascular permeability factor receptor; VEGF R1; VEGFR 1; VEGFR-1; VEGFR-2

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基因别名: CD309; FLK1; FLT; FLT-1; FLT1; FRT; KDR; VEGFR; VEGFR-1; Vegfr-2; VEGFR1; VEGFR2

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UniProt ID: (Human) P17948, (Human) P35968, (Rat) O08775

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Entrez Gene ID: (Human) 2321, (Rat) 54251, (Human) 3791, (Rat) 25589

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功能
transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding growth factor binding VEGF-A-activated receptor activity VEGF-B-activated receptor activity placental growth factor-activated receptor activity receptor signaling protein tyrosine kinase activity identical protein binding protein tyrosine kinase activity integrin binding Hsp90 protein binding vascular endothelial growth factor binding transmembrane signal receptor
参与通路
activation of MAPKK activity angiogenesis response to hypoxia monocyte chemotaxis regulation of smooth muscle contraction transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation positive regulation of phospholipase C activity positive regulation of phosphatidylinositol 3-kinase signaling cell migration peptidyl-tyrosine phosphorylation cell differentiation positive regulation of cell migration intracellular receptor signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-1 signaling pathway vascular endothelial growth factor signaling pathway positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway blood vessel morphogenesis embryonic morphogenesis positive regulation of smooth muscle cell proliferation patterning of blood vessels sprouting angiogenesis protein phosphorylation chemotaxis signal transduction by protein phosphorylation positive regulation of fibroblast proliferation vasculogenesis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis endothelium development regulation of cell shape positive regulation of endothelial cell migration viral process positive regulation of macroautophagy extracellular matrix organization embryonic hemopoiesis calcium-mediated signaling using intracellular calcium source positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine autophosphorylation negative regulation of apoptotic process positive regulation of positive chemotaxis positive regulation of nitric-oxide synthase biosynthetic process positive regulation of focal adhesion assembly positive regulation of mitochondrial depolarization positive regulation of ERK1 and ERK2 cascade positive regulation of mitochondrial fission negative regulation of endothelial cell apoptotic process positive regulation of vasculogenesis ovarian follicle development lymph vessel development positive regulation of mesenchymal cell proliferation endocardium development endochondral bone growth positive regulation of cytosolic calcium ion concentration aging male gonad development hemopoiesis hyaluronan metabolic process lung development positive regulation of BMP signaling pathway positive regulation of TOR signaling response to drug surfactant homeostasis negative regulation of neuron apoptotic process cell fate commitment endothelial cell differentiation regulation of endothelial cell differentiation positive regulation of vasodilation positive regulation of long-term neuronal synaptic plasticity lung alveolus development cell maturation branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of epithelial cell proliferation positive regulation of neurogenesis positive regulation of calcium-mediated signaling calcium ion homeostasis response to oxygen levels regulation of hematopoietic progenitor cell differentiation
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