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Invitrogen
VEGF Receptor 2 Monoclonal Antibody (4B4)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15556
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4B4
Immunogen
Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15556 targets KDR in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human samples.
The MA5-15556 immunogen is purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
MA5-15556 detects KDR which has a predicted molecular weight of approximately 152kDa.
Target Information
KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD309 antigen; fetal liver kinase-1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; sCD309; soluble CD309; soluble VEGFR 2; soluble VEGFR2; tyrosine kinase growth factor receptor; unnamed protein product; VEGF R2; VEGFR-2; tyrosine kinase
Gene Aliases: CD309; FLK1; VEGFR; VEGFR2
UniProt ID: (Human) P35968
Entrez Gene ID: (Human) 3791
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
integrin binding
protein binding
ATP binding
coreceptor activity
growth factor binding
vascular endothelial growth factor binding
identical protein binding
cadherin binding
Hsp90 protein binding
angiogenesis
patterning of blood vessels
vasculogenesis
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
vasculature development
endocardium development
endothelium development
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of endothelial cell migration
negative regulation of gene expression
positive regulation of macroautophagy
cell migration
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
positive regulation of BMP signaling pathway
embryonic hemopoiesis
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor receptor-2 signaling pathway
vascular endothelial growth factor signaling pathway
negative regulation of apoptotic process
regulation of MAPK cascade
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of blood vessel endothelial cell migration
endothelial cell differentiation
positive regulation of angiogenesis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
positive regulation of positive chemotaxis
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
positive regulation of mitochondrial depolarization
epithelial tube morphogenesis
vascular wound healing
positive regulation of ERK1 and ERK2 cascade
semaphorin-plexin signaling pathway
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of mitochondrial fission
positive regulation of nitric oxide-cGMP mediated signal transduction
cellular response to hydrogen sulfide
negative regulation of endothelial cell apoptotic process
positive regulation of endothelial cell chemotaxis
positive regulation of vasculogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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