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Invitrogen
VEGF Receptor 3 Recombinant Rabbit Monoclonal Antibody (005)
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产品信息
MA5-30605
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
005
抗原
Recombinant Human VEGFR3/FLT-4 Protein (Met1-Ile776)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human VEGFR3/FLT-4.
靶标信息
Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLT-4; Fms-like tyrosine kinase 4; fms-related tyrosine kinase 4; soluble VEGFR 3; sVEGFR 3; Tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; VEGF R3; VEGFR-3
基因别名: FLT-4; FLT4; FLT41; LMPH1A; PCL; VEGFR-3; VEGFR3
UniProt ID: (Human) P35916
Entrez Gene ID: (Human) 2324
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
vasculature development
lymph vessel development
lymphangiogenesis
sprouting angiogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
positive regulation of vascular endothelial growth factor production
positive regulation of endothelial cell migration
peptidyl-tyrosine phosphorylation
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor signaling pathway
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of JNK cascade
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
blood vessel morphogenesis
regulation of blood vessel remodeling
positive regulation of ERK1 and ERK2 cascade
positive regulation of protein kinase C signaling
