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VISTA Antibody (A700-035) in ICC/IF
Detection of human VISTA by immunocytochemistry.IHC. AntibodySample: FFPE section of NCI-H226 cells.Antibody: Rabbit anti-VISTA recombinant monoclonal antibody (BLR035F) (A700-035 lot 1) used at 1:250.Secondary: HRP-conjugated goat anti-rabbit IgG (A120-501P). Substrate: DAB.
产品信息
A700-035
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BLR035F
抗原
Peptide representing a region between residue 250 and the C-terminus (residue 311) of human V-type immunoglobulin domain-containing suppressor of T-cell activation precursor.
偶联物
形式
Liquid
浓度
100 µg/mL
纯化类型
purified
保存液
BBS, pH 7.8 to 8.6, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
靶标信息
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Death Domain1alpha; PD-H1; PDCD1 homolog; Platelet receptor Gi24; Sisp-1; Stress-induced secreted protein-1; V-domain Ig suppressor of T cell activation; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation
基因别名: B7-H5; B7H5; C10orf54; DD1alpha; GI24; PD-1H; PP2135; SISP1; UNQ730/PRO1412; VISTA; VSIR
UniProt ID: (Human) Q9H7M9
Entrez Gene ID: (Human) 64115
