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Invitrogen
VPS35 Recombinant Rabbit Monoclonal Antibody (HL1017)
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图: 1 / 10
VPS35 Antibody (MA5-42386) in ICC/IF
Immunofluorescence analysis of VPS35 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with VPS35 Recombinant Rabbit Monoclonal Antibody (HL1017) (Product # MA5-42386) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ Plus... View More
产品信息
MA5-42386
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Cat,
Human,
Mouse,
Rat,
Zebrafish
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1017
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human VPS35. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
靶标信息
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp434E1211; DKFZp434P1672; FLJ10752; FLJ13588; FLJ20388; hVPS35; Maternal embryonic message 3; Maternal-embryonic 3; MEM3; similar to Homo sapiens vacuolar sorting protein 35 (VPS35) mRNA with GenBank Accession Number AF191298; unnamed protein product; vacuolar protein sorting 35 homolog; Vacuolar protein sorting-associated protein 35; Vesicle protein sorting 35; VPS35
基因别名: AI647796; bZ34G2.3; MEM3; PARK17; si:rp71-34g2.3; TCCCTA00141; VPS35; wu:fa66e03; wu:fb95c08; zgc:136268
UniProt ID: (Human) Q96QK1, (Mouse) Q9EQH3
Entrez Gene ID: (Dog) 475346, (Human) 55737, (Rat) 25479, (Mouse) 65114, (Zebrafish) 561697
intracellular protein transport
lysosome organization
positive regulation of signal transduction
positive regulation of gene expression
negative regulation of gene expression
regulation of mitochondrion organization
protein transport
Wnt signaling pathway
regulation of macroautophagy
regulation of protein stability
protein destabilization
endocytic recycling
negative regulation of protein homooligomerization
protein localization to organelle
protein localization to endosome
retrograde transport, endosome to Golgi
regulation of protein catabolic process
mitochondrial fragmentation involved in apoptotic process
transcytosis
positive regulation of protein catabolic process
negative regulation of inflammatory response
regulation of developmental process
modulation of synaptic transmission
voluntary musculoskeletal movement
regulation of transport
regulation of protein metabolic process
positive regulation of dopamine receptor signaling pathway
positive regulation of Wnt protein secretion
regulation of synapse maturation
positive regulation of mitochondrial fission
positive regulation of canonical Wnt signaling pathway
positive regulation of locomotion involved in locomotory behavior
neurotransmitter receptor transport, endosome to postsynaptic membrane
vesicle-mediated transport in synapse
mitochondrion to lysosome transport
regulation of postsynapse organization
neurotransmitter receptor transport, endosome to plasma membrane
regulation of postsynapse assembly
negative regulation of late endosome to lysosome transport
regulation of dendritic spine maintenance
positive regulation of dopamine biosynthetic process
negative regulation of cellular protein localization
positive regulation of cellular protein localization
positive regulation of protein localization to cell periphery
negative regulation of lysosomal protein catabolic process
regulation of presynapse assembly
regulation of terminal button organization
retrograde transport, endosome to plasma membrane
vacuolar protein processing
transport
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