Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
图: 1 / 17
OMA1-06001 detects vimentin from mouse, rat, hamster, chicken, goat, canine, monkey, zebrafish, porcine and human tissues and cells.
OMA1-06001 has been successfully used in Western blot, immunofluorescence, immunocytochemistry, flow cytometry, and immunohistochemistry (frozen) procedures. By Western blot, this antibody detects a ~57 kDa protein representing vimentin from human mesenchymal cells.
OMA1-06001 antigen is cytoskeletal vimentin extract of calf lens.
Store at 4ºC or at -20ºC if preferred. Avoid freeze-thaw cycles.
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: epididymis luminal protein 113; FLJ36605; intermediate filament; intermediate filament protein; RP11-124N14.1; VIME; Vimentin; vimentin C-terminus
基因别名: cb28; CTRCT30; HEL113; VIM
UniProt ID: (Pig) P02543, (Bovine) P48616, (Human) Q6LER9, (Mouse) P20152, (Rat) P31000