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NeoBiotechnologies
Vinculin (Marker of Age-related Macular Degeneration) Recombinant Rabbit Monoclonal Antibody (VCL/7091R)
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Vinculin (Marker of Age-related Macular Degeneration) Antibody (7414-RBM6-P1) in IHC (P)
Formalin-fixed, paraffin-embedded human placenta stained with Vinculin Recombinant Rabbit Monoclonal Antibody (VCL/7091R) at 2 µg/mL. Inset: PBS instead of primary antibody; secondary only negative control.
产品信息
7414-RBM6-P1
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
VCL/7091R
抗原
Recombinant fragment (around aa 174-322) of human Vinculin (VCL) protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: A431, K562, NIH3T3, U-87 or THP-1 cells. Human bladder or testis. Cellular Localization: Cytoplasm
Specificity Comments: Focal adhesions are identified as areas within the plasma membrane of tissue culture cells that adhere tightly to the underlying substrate. In vivo, these regions are involved in the adhesion of cells to the extracellular matrix. Paxillin and vinculin are cytoskeletal, focal adhesion proteins that are components of a protein complex which links the Actin network to the plasma membrane. Vinculin binding sites have been identified on other cytoskeletal proteins, including Talin and -Actinin has been shown to link Actin to integrins in the plasma membrane through interactions with the vinculin and Talin complex or by a direct interaction with integrin.
靶标信息
Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis luminal protein 114; Metavinculin; MV; RP11-178G16.3; vinc; Vinculin
基因别名: 9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; HEL114; MV; MVCL; VCL
UniProt ID: (Human) P18206, (Mouse) Q64727
Entrez Gene ID: (Human) 7414, (Mouse) 22330
morphogenesis of an epithelium
cell adhesion
cell-matrix adhesion
lamellipodium assembly
regulation of cell migration
adherens junction assembly
protein localization to cell surface
apical junction assembly
axon extension
platelet aggregation
epithelial cell-cell adhesion
platelet degranulation
movement of cell or subcellular component
muscle contraction
negative regulation of cell migration
