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Invitrogen
Viral MCV type II Polyclonal Antibody
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产品信息
PA5-149278
产品规格
种属反应
Virus
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant viral MCV-type II Chemokine-like Protein
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
MCV Type II refers to the Merkel cell polyomavirus (MCV or MCPyV) type II, which is one of the most significant risk factors for Merkel cell carcinoma (MCC), a rare but aggressive form of skin cancer. MCV is a member of the polyomavirus family and is commonly found in the skin of healthy individuals, where it usually remains asymptomatic. However, in certain circumstances, such as immunosuppression or UV exposure, MCV can integrate into the host genome and become oncogenic. The integration typically disrupts the viral genome, leading to the expression of viral oncoproteins, such as the large T antigen and small T antigen, which interfere with cell cycle regulation and promote uncontrolled cell proliferation. MCV Type II is one of the variants of this virus, characterized by specific genetic sequences that may influence its pathogenicity and the host's immune response. Understanding the molecular biology of MCV Type II, including its mechanisms of integration and oncogenesis, is crucial for developing diagnostic, preventive, and therapeutic strategies for MCC. Research into MCV Type II also provides broader insights into viral-induced carcinogenesis and the potential for targeting viral components in cancer treatment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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