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Invitrogen
Viral MIP-III Monoclonal Antibody (76621)
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产品信息
MA5-61749
产品规格
种属反应
Virus
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
76621
抗原
E. coli-derived recombinant human herpes virus-8 MIP-III, Ser27-Pro114
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
MIP-III, also known as CCL28 (C-C motif chemokine ligand 28), is a chemokine gene that plays a significant role in the immune system by directing the migration of immune cells to sites of inflammation and infection. The protein encoded by MIP-III is a member of the CC chemokine family and is primarily expressed in mucosal tissues such as the intestines, lungs, and mammary glands. MIP-III is known to attract a variety of immune cells, including T cells, B cells, and eosinophils, by binding to its receptors CCR3 and CCR10. This chemokine is involved in the mucosal immune response, helping to maintain immune surveillance and protect against pathogens. Additionally, MIP-III has been implicated in the pathogenesis of inflammatory diseases and allergic reactions due to its role in recruiting immune cells to affected tissues. Understanding the function and regulation of MIP-III is important for developing therapeutic strategies aimed at modulating immune cell trafficking in conditions such as inflammatory bowel disease, asthma, and other mucosal inflammatory disorders. Research into MIP-III also provides insights into the mechanisms of immune cell migration and the potential for targeting chemokines in immunotherapy.
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