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Invitrogen
Vonlerizumab Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA5-59895
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Vonlerizumab, also known as an anti-human CD134 (OX40) monoclonal antibody, is extensively studied for its targeted immunomodulatory function. TNFRSF4, also known as OX40 or CD134, is a gene encoding a protein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. This receptor is primarily expressed on activated CD4 and CD8 T cells and serves as a co-stimulatory molecule involved in the regulation of immune responses. Upon binding with its ligand, OX40L (CD252), OX40 transmits signals that promote T cell proliferation, survival, and cytokine production, thereby enhancing the immune response. The expression of the OX40 gene is tightly controlled and can be upregulated by chromatin remodeling in T cells. OX40 signaling plays a crucial role in the accumulation of protective T cells during anti-viral and anti-tumor immune responses and is being explored as a therapeutic target in both autoimmune diseases and cancer immunotherapy due to its ability to modulate T cell-mediated immune functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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