Invitrogen

WAVE2 Recombinant Rabbit Monoclonal Antibody (1E12)

Name: WAVE2 Recombinant Rabbit Monoclonal Antibody (1E12)
Brand: Invitrogen
SKU: MA572544

查看其他10个WAVE2抗体

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

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WAVE2 Antibody (MA572544) in WB

Western blot analysis of WAVE2 in PC-3 lysates (25 µg/lane). Samples were incubated with WAVE2 Recombinant Monoclonal (Product # MA572544) at 1:1,000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at room temperature for 60 min.

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产品信息

MA572544

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:100-1:200

免疫组化（冰冻） (IHC (F))

1:100-1:200

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

1E12

抗原

KLH conjugated synthetic peptide derived from human WASF2.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.75 mg/mL

75 µg

纯化类型

Protein A

保存液

TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Actin-binding protein WASF2; Protein WAVE-2; putative Wiskott-Aldrich syndrome protein family member 4; suppressor of cyclic-AMP receptor (WASP-family); unnamed protein product; Verprolin homology domain-containing protein 2; WAS protein family member 2; WASP family protein member 2; WASP family protein member 4; WASP family Verprolin-homologous protein 2; Wiskott-Aldrich syndrome protein family member 2

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基因别名: dJ393P12.2; IMD2; SCAR2; WASF2; WASF4; WAVE2

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UniProt ID: (Human) Q9Y6W5

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Entrez Gene ID: (Human) 10163

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功能

actin binding protein binding SH3 domain binding protein kinase A regulatory subunit binding cadherin binding protein kinase A binding Arp2/3 complex binding

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