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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: MLLDVAVSPD DRFILTADRD EKIRVSWAAA PHSIESFCLG HTEFVSRISV VPTQPGLLLS SSGDGTLRLW EYRSGRQLHC CHLASLQELV DPQAPQKFAA SRIAFWCQEN CVALLCDGTS VVYIFQLDAR RQQLVYRQQL AFQHQVWDVA FEETQGLWVL QDCQEAPLVL YRPVGDQWQS VPESTVLKKV SGVLRGNWAM LEGSAGADAS FSSLYKATFD NVTSYLKKKE ERLQQQLEKK QRRRSPPPGP DGHAKKMRPG EATLSC
Required for 7-methylguanosine modification of tRNA. This protein is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD). which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes. including cell cycle progression. signal transduction. apoptosis. and gene regulation. This protein is excluded as a candidate for a form of nonsyndromic deafness (DFNB10). but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternative splicing of this gene generates at least 3 transcript variants. two of which diverge at the 3' UTR and thus encode the same protein products.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: hWH; Protein Wuho homolog; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4
基因别名: WDR4
Entrez Gene ID: (Human) 10785