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Immunogen sequence: TSSQDNSVKF WDYRQPRKYL NILPCQVPVW KARYTPFSNG LVTVMVPQLR RENSLLLWNV FDLNTPVHTF VGHDDVVLEF QWRKQKEGSK D
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 99%.
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GATOR2 complex protein WDR59; WD repeat-containing protein 59
基因别名: FP977; KIAA1923; WDR59
UniProt ID: (Human) Q6PJI9
Entrez Gene ID: (Human) 79726