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Invitrogen
WFS1 Recombinant Rabbit Monoclonal Antibody (0J9H6)
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WFS1 Antibody (MA575403) in IHC (P)
Immunohistochemistry analysis of WFS1 in paraffin-embedded rat brain. Samples were treated with antigen retrieval using 10 mM citrate buffer (pH 6.0), then incubated with monoclonal WFS1 (Product # MA575403) antibody at a dilution of 1:100, followed by Cy3-conjugated Goat anti-Rabbit IgG (H+L) (1:500) and DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA575403
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
0J9H6
抗原
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.05 mg/mL
规格
105 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 0.05% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: unnamed protein product; Wolfram antibody; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 (wolframin) isoform WFS1_1; Wolfram syndrome 1 (wolframin) isoform WFS1_2; Wolfram syndrome 1 homolog
基因别名: CTRCT41; WFRS; WFS; WFSL
UniProt ID: (Human) O76024
Entrez Gene ID: (Human) 7466, (Rat) 83725
negative regulation of transcription from RNA polymerase II promoter
kidney development
renal water homeostasis
ER overload response
visual perception
sensory perception of sound
endoplasmic reticulum unfolded protein response
pancreas development
positive regulation of protein ubiquitination
endoplasmic reticulum calcium ion homeostasis
response to endoplasmic reticulum stress
intracellular signal transduction
ERAD pathway
olfactory behavior
glucose homeostasis
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of neuron apoptotic process
positive regulation of growth
protein stabilization
neurological system process
positive regulation of protein metabolic process
positive regulation of calcium ion transport
calcium ion homeostasis
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of intracellular signal transduction
negative regulation of response to endoplasmic reticulum stress
negative regulation of ATF6-mediated unfolded protein response
negative regulation of type B pancreatic cell apoptotic process
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