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Invitrogen
WISP1 Polyclonal Antibody
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产品信息
PA5151205
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide located within the following region: aa 160-209.
偶联物
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The immunogen sequence is: VRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEV
靶标信息
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CCN family member 4; unnamed protein product; WISP-1; WISP1 3'UTR-associated RNA 1; WISP1 overlapping transcript 1 (non-protein coding); WISP1vx; Wnt-1-induced secreted protein; WNT1 induced secreted protein 1; WNT1 inducible signaling pathway protein 1; WNT1-inducible-signaling pathway protein 1
基因别名: CCN4; WISP1; WISP1-OT1; WISP1-UT1; WISP1c; WISP1i; WISP1tc
UniProt ID: (Human) O95388
Entrez Gene ID: (Human) 8840
osteoblast differentiation
regulation of cytokine production
cell adhesion
signal transduction
cell-cell signaling
positive regulation of smooth muscle cell migration
Wnt signaling pathway
positive regulation of Wnt signaling pathway
osteoclast differentiation
negative regulation of chondrocyte differentiation
glucose homeostasis
regulation of cell differentiation
positive regulation of cell differentiation
negative regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
regulation of multicellular organismal process
bone development
positive regulation of wound healing
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