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Invitrogen
WNT7A Polyclonal Antibody
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FIGURE: 1 / 1
WNT7A Antibody (PA5-96320) in WB
Western blot analysis of WNT7A in BeWo cells. Samples were incubated with WNT7A Polyclonal antibody (Product # PA5-96320) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-96320
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 101-200 of human WNT7A (NP_0046162)
Conjugate
Form
Liquid
Concentration
1.28 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Mouse kidney; Cellular Location: extracellular matrix, extracellular space
Immunogen sequence: KEKQGQYHRD EGWKWG
Target Information
Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to induce the expression of numerous genes. Increased Wnt/β-catenin signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: postaxial hemimelia; Protein Wnt-7a; proto-oncogene Wnt7a protein; wingless-related MMTV integration site 7A; wingless-type MMTV integration site family member 7A; wingless-type MMTV integration site family, member 7A
Gene Aliases: AI849442; px; tw; Wnt-7a; WNT7A
UniProt ID: (Human) O00755, (Mouse) P24383
Entrez Gene ID: (Human) 7476, (Mouse) 22421
embryonic axis specification
cartilage condensation
angiogenesis
chondrocyte differentiation
neurotransmitter secretion
axonogenesis
synapse assembly
sex differentiation
asymmetric protein localization
dorsal/ventral pattern formation
positive regulation of endothelial cell migration
skeletal muscle satellite cell activation
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
Wnt signaling pathway
cerebellar granule cell differentiation
cell proliferation in forebrain
central nervous system vasculogenesis
establishment of cell polarity
regulation of axon diameter
response to estradiol
somatic stem cell population maintenance
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
non-canonical Wnt signaling pathway
Wnt signaling pathway involved in wound healing, spreading of epidermal cells
synaptic vesicle recycling
embryonic digit morphogenesis
negative regulation of apoptotic process
response to estrogen
cell fate commitment
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
somatic stem cell division
stem cell development
negative regulation of neurogenesis
positive regulation of synapse assembly
palate development
positive regulation of epithelial cell proliferation involved in wound healing
oviduct development
canonical Wnt signaling pathway
dendritic spine morphogenesis
uterus morphogenesis
lens fiber cell development
cellular response to transforming growth factor beta stimulus
positive regulation of canonical Wnt signaling pathway
positive regulation of protein localization to synapse
excitatory synapse assembly
positive regulation of excitatory synapse assembly
positive regulation of excitatory postsynaptic potential
signal transduction
cell-cell signaling
multicellular organism development
positive regulation of cell proliferation
organ morphogenesis
positive regulation of gene expression
embryonic limb morphogenesis
forelimb morphogenesis
hindlimb morphogenesis
regulation of cell proliferation
skin morphogenesis
reproductive structure development
skeletal system morphogenesis
regulation of axonogenesis
synapse organization
cartilage development
uterus development
limb development
positive regulation of receptor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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