Invitrogen

WNT7A Recombinant Mouse Monoclonal Antibody (K8U018_3H2)

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说明书
实验方案
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说明书
实验方案
问题与答案
技术支持
WNT7A Recombinant Mouse Monoclonal Antibody (K8U018_3H2)

产品信息

MA564433

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:200
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG2a

Expression System

CHO cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K8U018_3H2

抗原

Recombinant human WNT7A (aa 231-310).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS with 50% glycerol, 0.5% BSA

内含物

0.09% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3705520

产品详细信息

Immunogen sequence: KYNEAVHVEP VRASRNKRPT FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ ASGCDLMCCG

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 42%, Pig - 100%, Cynomolgus monkey - 100%.

靶标信息

Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to induce the expression of numerous genes. Increased Wnt/β-catenin signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: postaxial hemimelia; Protein Wnt-7a; proto-oncogene Wnt7a protein; wingless-related MMTV integration site 7A; wingless-type MMTV integration site family member 7A; wingless-type MMTV integration site family, member 7A

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基因别名: AI849442; px; tw; Wnt-7a; WNT7A

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UniProt ID: (Human) O00755, (Mouse) P24383

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Entrez Gene ID: (Human) 7476, (Mouse) 22421

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功能
receptor binding frizzled binding cytokine activity protein binding receptor agonist activity intercellular signal molecule
参与通路
embryonic axis specification cartilage condensation angiogenesis chondrocyte differentiation neurotransmitter secretion axonogenesis synapse assembly sex differentiation asymmetric protein localization dorsal/ventral pattern formation positive regulation of endothelial cell migration skeletal muscle satellite cell activation skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Wnt signaling pathway cerebellar granule cell differentiation cell proliferation in forebrain central nervous system vasculogenesis establishment of cell polarity regulation of axon diameter response to estradiol somatic stem cell population maintenance embryonic forelimb morphogenesis embryonic hindlimb morphogenesis non-canonical Wnt signaling pathway Wnt signaling pathway involved in wound healing, spreading of epidermal cells synaptic vesicle recycling embryonic digit morphogenesis negative regulation of apoptotic process response to estrogen cell fate commitment positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade somatic stem cell division stem cell development negative regulation of neurogenesis positive regulation of synapse assembly palate development positive regulation of epithelial cell proliferation involved in wound healing oviduct development canonical Wnt signaling pathway dendritic spine morphogenesis uterus morphogenesis lens fiber cell development cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway positive regulation of protein localization to synapse excitatory synapse assembly positive regulation of excitatory synapse assembly positive regulation of excitatory postsynaptic potential signal transduction cell-cell signaling multicellular organism development positive regulation of cell proliferation organ morphogenesis positive regulation of gene expression embryonic limb morphogenesis forelimb morphogenesis hindlimb morphogenesis regulation of cell proliferation skin morphogenesis reproductive structure development skeletal system morphogenesis regulation of axonogenesis synapse organization cartilage development uterus development limb development positive regulation of receptor activity
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