Invitrogen

WNT7A/WNT7B Polyclonal Antibody

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
WNT7A/WNT7B Polyclonal Antibody

产品信息

PA5-47430

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1 µg/mL
-

免疫组化（石蜡） (IHC (P))

5-15 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

E. coli-derived recombinant human Wnt-7a Leu32-Glu72, Thr216-Arg292
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2610494

产品详细信息

In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant mouse (rm) Wnt-1, rmWnt-3a, rmWnt-4, rmWnt-5a, rmWnt-5b, rmWnt-9a, rmWnt-11, and rmWnt-16 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

靶标信息

Wnt proteins constitute a family of secreted glycoproteins that activate signal transduction pathways to mediate tissue homeostasis, cell fate, cell proliferation, and self-renewal. The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade. Non-canonical Wnt signals are activated by binding to a Frizzled family receptor and ROR2 coreceptor. Extensive research has shown that deregulation of these pathways or its components can lead to cancer. Human Wnt-1 is encoded as a 370 amino acid precursor that, upon secretion, is cleaved into a 343 amino acid (42 kDa) mature form. At the amino acid level, mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1. Depending on the tissue, Wnt-1 can activate the canonical and non-canonical signaling pathways. Studies have demonstrated its involvement in a variety of functions, including embryonic development and carcinogenesis. Wnt-1 signaling can also induce the phosphorylation and subsequent degradation of c-Myb.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Protein Wnt-7a; Protein Wnt-7b; proto-oncogene Wnt7a protein; wingless-type MMTV integration site family member 7A; wingless-type MMTV integration site family member 7B; wingless-type MMTV integration site family, member 7A; wingless-type MMTV integration site family, member 7B

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基因别名: WNT7A; WNT7B

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UniProt ID: (Human) O00755, (Human) P56706

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Entrez Gene ID: (Human) 7476, (Human) 7477

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功能
receptor binding frizzled binding cytokine activity protein binding receptor agonist activity intercellular signal molecule
参与通路
embryonic axis specification cartilage condensation angiogenesis chondrocyte differentiation neurotransmitter secretion axonogenesis synapse assembly sex differentiation asymmetric protein localization dorsal/ventral pattern formation positive regulation of endothelial cell migration skeletal muscle satellite cell activation skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Wnt signaling pathway cerebellar granule cell differentiation cell proliferation in forebrain central nervous system vasculogenesis establishment of cell polarity regulation of axon diameter response to estradiol somatic stem cell population maintenance embryonic forelimb morphogenesis embryonic hindlimb morphogenesis non-canonical Wnt signaling pathway Wnt signaling pathway involved in wound healing, spreading of epidermal cells synaptic vesicle recycling embryonic digit morphogenesis negative regulation of apoptotic process response to estrogen cell fate commitment positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade somatic stem cell division stem cell development negative regulation of neurogenesis positive regulation of synapse assembly palate development positive regulation of epithelial cell proliferation involved in wound healing oviduct development canonical Wnt signaling pathway dendritic spine morphogenesis uterus morphogenesis lens fiber cell development cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway positive regulation of protein localization to synapse excitatory synapse assembly positive regulation of excitatory synapse assembly positive regulation of excitatory postsynaptic potential in utero embryonic development metanephros morphogenesis establishment or maintenance of polarity of embryonic epithelium forebrain regionalization neuron differentiation lung development oxygen homeostasis homeostatic process cellular metabolic process positive regulation of osteoblast differentiation fibroblast proliferation embryonic organ development synapse organization lung morphogenesis lung epithelium development lobar bronchus development trachea cartilage morphogenesis developmental growth involved in morphogenesis embryonic placenta morphogenesis chorio-allantoic fusion mammary gland epithelium development cellular response to retinoic acid renal inner medulla development renal outer medulla development outer medullary collecting duct development inner medullary collecting duct development stem cell proliferation metanephric collecting duct development metanephric epithelium development metanephric loop of Henle development
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