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Invitrogen
WNT8A Recombinant Rabbit Monoclonal Antibody (PSH0-39)
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WNT8A Antibody (MA5-50826) in ICC/IF
Immunocytochemistry analysis of WNT8A in NIH/3T3 cells. Cells were fixed in 4% paraformaldehyde for 10 minutes at 37 &(8)451;, permeabilized with 0.05% Triton X-100 in PBS for 20 minutes, and then blocked with 2% negative goat serum for 30 minutes at room temperature. Cells were incubated with WNT8A recombinant monoclonal antibody (Product # MA5-50826) with a dilution of 1:50 in 2% negative goat serum overnight at 4 &(8)451;. Followed by secondary antibody Goat Anti-Rabbit IgG H&L (iFluor™ 488) at a dilution of 1:1,000. Nuclear DNA was lab... View More
产品信息
MA5-50826
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH0-39
抗原
Recombinant protein within human WNT8A aa 100-300/351.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive control: HeLa cell lysate, HepG2 cell lysate, SW480 cell lysate, Jurkat cell lysate, Raji cell lysate, NIH/3T3 cell lysate, mouse brain tissue lysate, mouse embryo tissue lysate, rat brain tissue lysate, NIH/3T3, HeLa.
Predicted band size: 38.8 kDa
Subcellular Location: Secreted, extracellular space, extracellular matrix.
靶标信息
WNT8A, part of the WNT gene family, consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein Wnt-8a; Protein Wnt-8d; Stimulated by retinoic acid gene 11 protein; wingless-related MMTV integration site 8A; wingless-related MMTV integration site 8D; wingless-type MMTV integration site family member 8A; wingless-type MMTV integration site family, member 8A; wnt-8; WNT8d
基因别名: Stra11; Wnt-8A; Wnt-8D; WNT8A; WNT8D
UniProt ID: (Human) Q9H1J5, (Mouse) Q64527
Entrez Gene ID: (Human) 7478, (Mouse) 20890, (Rat) 291678
neural crest cell fate commitment
Wnt signaling pathway
neuron differentiation
response to retinoic acid
regulation of transcription involved in anterior/posterior axis specification
canonical Wnt signaling pathway involved in neural crest cell differentiation
palate development
canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
beta-catenin destruction complex disassembly
cell morphogenesis
regionalization
multicellular organism development
endoderm development
polarity specification of anterior/posterior axis
polarity specification of proximal/distal axis
regulation of protein localization
cell fate commitment
establishment of organ orientation
biological_process
