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Antibodies Inc
WRN Monoclonal Antibody (N428/12)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
75-423
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N428/12
抗原
Fusion protein amino acids 38-236 (exonuclease domain) of human WRN (accession number Q14191) produced recombinantly in E. Coli.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; DKFZp686C2056; DNA helicase, RecQ-like type 3; RecQ protein-like 2; similar to Werner syndrome helicase homolog; Werner syndrome protein
基因别名: RECQ3; RECQL2; WRN
Entrez Gene ID: (Rat) 290805
magnesium ion binding
Y-form DNA binding
bubble DNA binding
nucleic acid binding
DNA binding
DNA helicase activity
ATP-dependent DNA helicase activity
helicase activity
exonuclease activity
ATP binding
3'-5' exonuclease activity
four-way junction helicase activity
ATPase activity
manganese ion binding
protein complex binding
protein homodimerization activity
3'-5' DNA helicase activity
ATP-dependent 3'-5' DNA helicase activity
G-quadruplex DNA binding
DNA helicase
telomere maintenance
DNA synthesis involved in DNA repair
replicative cell aging
DNA metabolic process
DNA replication
DNA repair
base-excision repair
double-strand break repair
DNA recombination
cellular response to DNA damage stimulus
response to oxidative stress
cell aging
cellular response to starvation
response to UV-C
multicellular organism aging
replication fork processing
nucleolus to nucleoplasm transport
DNA duplex unwinding
regulation of growth rate
regulation of apoptotic process
positive regulation of hydrolase activity
cellular response to gamma radiation
nucleic acid phosphodiester bond hydrolysis
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