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Bethyl Laboratories
WRNIP1 Polyclonal Antibody
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FIGURE: 1 / 3
WRNIP1 Antibody (IHC-00282) in IHC (P)
Detection of human WRNIP1 by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-WRNIP1 (Product # IHC-00282) used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody used at a dilution of 1:100.
Product Details
IHC-00282
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 400 and 450 of Human Werner helicase interacting protein 1.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Dog, Horse, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Naked mole rat, Chinese hamster and Small-eared galago
Target Information
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase WRNIP1; FLJ22526; putative helicase RUVBL; RP11-420G6.2; Werner helicasae interacting protein 1; Werner helicase-interacting protein 1; Werner syndrome homolog interacting protein; WRNIP1
Gene Aliases: 4833444L21Rik; bA420G6.2; WHIP; Wrnip; WRNIP1
UniProt ID: (Human) Q96S55, (Mouse) Q91XU0
Entrez Gene ID: (Human) 56897, (Mouse) 78903
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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