Invitrogen

WWOX Monoclonal Antibody (3D10)

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WWOX Monoclonal Antibody (3D10)

产品信息

MA5-49188

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL
-

免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL
-

免疫细胞化学 (ICC/IF)

5 µg/mL
-

流式细胞分析 (Flow)

1-3 µg/1x10^6 cells
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

3D10

抗原

E. coli-derived human WWOX recombinant protein (Position: M1-D245).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 4mg trehalose

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3074846

产品详细信息

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Positive Control - WB: human placenta tissue, human T-47D whole cell, human HepG2 whole cell, human U-87MG whole cell, human A549 whole cell, human Hela whole cell, human PC-3 whole cell, human Caco-2 whole cell, rat testicular tissue, rat brain tissue, rat liver tissue, mouse testicular tissue, mouse brain tissue, mouse liver tissue, mouse NIH/3T3 whole cell. IHC: human mammary cancer tissue, human ovarian cancer tissue, rat testis tissue, mouse testis tissue. ICC/IF: A431 cell. Flow: U20S cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1; short chain dehydrogenase/reductase family 41C, member 1; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; WW-domain oxidoreductase

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基因别名: 5330426P09Rik; 9030416C10Rik; D16S432E; EIEE28; FOR; FRA16D; HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1; WWOX

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UniProt ID: (Human) Q9NZC7, (Mouse) Q91WL8

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Entrez Gene ID: (Human) 51741, (Mouse) 80707, (Rat) 292041

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功能
RNA polymerase II transcription coactivator activity protein binding oxidoreductase activity enzyme binding protein dimerization activity cofactor binding coenzyme binding C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity aldo-keto reductase (NADP) activity isocitrate dehydrogenase activity mevaldate reductase activity gluconate dehydrogenase activity steroid dehydrogenase activity epoxide dehydrogenase activity 5-exo-hydroxycamphor dehydrogenase activity 2-hydroxytetrahydrofuran dehydrogenase activity acetoin dehydrogenase activity phenylcoumaran benzylic ether reductase activity D-xylose:NADP reductase activity L-arabinose:NADP reductase activity D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor steroid dehydrogenase activity, acting on the CH-CH group of donors (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 3-hydroxymenthone dehydrogenase activity very long-chain-3-hydroxyacyl-CoA dehydrogenase activity dihydrotestosterone 17-beta-dehydrogenase activity (R)-2-hydroxyisocaproate dehydrogenase activity L-arabinose 1-dehydrogenase (NADP+) activity L-xylulose reductase (NAD+) activity 3-ketoglucose-reductase activity (R)-2-hydroxyglutarate dehydrogenase activity D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity molecular_function transcription cofactor
参与通路
osteoblast differentiation steroid metabolic process Wnt signaling pathway negative regulation of Wnt signaling pathway positive regulation of transcription from RNA polymerase II promoter skeletal system morphogenesis oxidation-reduction process cellular response to transforming growth factor beta stimulus intrinsic apoptotic signaling pathway by p53 class mediator extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway in absence of ligand apoptotic process metabolic process biological_process
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