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Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ12610; Non-homologous end-joining factor 1; nonhomologous end-joining factor 1; Protein cernunnos; XRCC4-like factor
基因别名: 1700029B21Rik; cernunnos; NHEJ1; XLF
UniProt ID: (Human) Q6IA64, (Mouse) Q3KNJ2, (Rat) Q6AYI4
Entrez Gene ID: (Human) 79840, (Mouse) 75570, (Rat) 363251