Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
XRCC3 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
PA1-16535
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Hamster,
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic partial peptide of human XRCC3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is specific for XRCC3; no cross-reactivity was observed with XRCC2, RAD51, RAD51B, RAD51C, or RAD51D.
This antibody is not recommended for ICC/IF applications.
Suggested positive control: antigen standard for XRCC3 (transient overexpression lysate), TK6 lysates and 100 µg HeLa lysates.
Target Information
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA repair protein XRCC3; RAD51 like; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross-complementing protein 3; XRCC 3
Gene Aliases: CMM6; I79_004699; XRCC3
UniProt ID: (Human) O43542
Entrez Gene ID: (Human) 7517, (Chinese hamster) 103161145
meiotic DNA recombinase assembly
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA synthesis involved in DNA repair
strand displacement
DNA repair
DNA recombination
cellular response to DNA damage stimulus
reciprocal meiotic recombination
response to organic substance
response to ionizing radiation
regulation of centrosome duplication
interstrand cross-link repair
strand invasion
resolution of mitotic recombination intermediates
positive regulation of mitotic cell cycle spindle assembly checkpoint
t-circle formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support