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Invitrogen
ZAK Polyclonal Antibody
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产品信息
PA5-89875
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 100-312 of human ZAK (NP_5984071)
偶联物
形式
Liquid
浓度
1.76 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EEMDMDHIMT WATDVAKGMH YLHMEAPVKV IHRDLKSRNV VIAADGVLKI CDFGASRFHN HTTHMSLVGT FPWMAPEVIQ SLPVSETCDT YSYGVVLWEM LTREVPFKGL EGLQVAWLVV EKNERLTIPS SCPRSFAELL HQCWEADAKK RPSFKQIISI LESMSNDTSL PDKCNSFLHN KAEWRCEIEA TLERLKKLER DLSFKEQELK ERE; Positive Samples: Mouse heart, Mouse brain, Mouse skeletal muscle, Rat heart, Rat skeletal muscle; Cellular Location: Cytoplasm, Nucleus
靶标信息
ZAK is a leucine zipper-containing mitogen-activated protein related to the MLKs in both sequence and function. Like the MLKs and other MAP3Ks, ZAK activates MAP2Ks. ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif. This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Leucine zipper- and sterile alpha motif kinase ZAK; Leucine zipper- and sterile alpha motif-containing kinase; Mitogen-activated protein kinase kinase kinase 20; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase-related kinase; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MRK; sterile alpha motif and leucine zipper containing kinase AZK; Sterile alpha motif- and leucine zipper-containing kinase AZK; sterile-alpha motif and leucine zipper containing kinase AZK
基因别名: AV006891; B230120H23Rik; Map3k20; MLTK; MLTKalpha; MLTKbeta; RGD1561394; Zak
UniProt ID: (Mouse) Q9ESL4
Entrez Gene ID: (Mouse) 65964, (Rat) 311743
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
poly(A) RNA binding
metal ion binding
immunoglobulin
non-receptor serine/threonine protein kinase
cell cycle checkpoint
DNA damage checkpoint
MAPK cascade
activation of MAPKK activity
protein phosphorylation
cytoskeleton organization
cell cycle
cell cycle arrest
activation of JUN kinase activity
response to radiation
phosphorylation
intracellular signal transduction
positive regulation of apoptotic process
