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Invitrogen
ZBTB2 Polyclonal Antibody
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Product Details
PA5-110888
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human ZBTB2. Recombinant protein control fragment (Product #RP-93662).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TGVPFTSSQQ GESRVPLTLC SNAADLGKDA MEVPEAGMIS DSELQHISDS PIIDGQQQSE TPPPSDIADI DNLEQADQER EVKRRKYE
Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 91%.
Target Information
ZBTB2 is a transcription factor gene that belongs to the BTB/POZ zinc-finger family, characterized by a BTB/POZ domain at the N-terminus and multiple zinc-finger domains at the C-terminus. This gene is known for its role in regulating gene expression, particularly in the repression of genes like ARF, p53, and p21, and it functions as both a repressor and activator. ZBTB2 interacts with a variety of proteins involved in complex biological processes such as RNA processing, transcription regulation, and DNA packaging. Its zinc-finger domains predominantly belong to C2H2 and PHD types. ZBTB2 is involved in nucleosome remodeling through its interaction with chromatin modifiers and histone chaperones during developmental cell state transitions. The gene has been implicated in human cancers, where it functions as an oncogene, particularly in gastric cancers, and plays a role in the development of chronic myeloid leukemia. ZBTB2's localization at promoter regions is noted for colocalizing with several other chromatin-modifying proteins like EP400, KAT5, MBD3, and CHD4, indicating its significant role in chromatin dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Zinc finger and BTB domain-containing protein 2; ZNF909
Gene Aliases: KIAA1483; ZBTB2; ZNF437
UniProt ID: (Human) Q8N680
Entrez Gene ID: (Human) 57621
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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