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Invitrogen
ZBTB2 Polyclonal Antibody
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产品信息
PA5-20659
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 14 amino acid peptide near the center of human ZBTB2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is PC-3 cell lysate.
PA5-20659 can be used with blocking peptide PEP-0779.
靶标信息
ZBTB2 is a transcription factor gene that belongs to the BTB/POZ zinc-finger family, characterized by a BTB/POZ domain at the N-terminus and multiple zinc-finger domains at the C-terminus. This gene is known for its role in regulating gene expression, particularly in the repression of genes like ARF, p53, and p21, and it functions as both a repressor and activator. ZBTB2 interacts with a variety of proteins involved in complex biological processes such as RNA processing, transcription regulation, and DNA packaging. Its zinc-finger domains predominantly belong to C2H2 and PHD types. ZBTB2 is involved in nucleosome remodeling through its interaction with chromatin modifiers and histone chaperones during developmental cell state transitions. The gene has been implicated in human cancers, where it functions as an oncogene, particularly in gastric cancers, and plays a role in the development of chronic myeloid leukemia. ZBTB2's localization at promoter regions is noted for colocalizing with several other chromatin-modifying proteins like EP400, KAT5, MBD3, and CHD4, indicating its significant role in chromatin dynamics.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Zinc finger and BTB domain-containing protein 2; ZNF909
基因别名: Gm1103; KIAA1483; ZBTB2; ZNF437
UniProt ID: (Human) Q8N680
Entrez Gene ID: (Human) 57621, (Rat) 308126, (Mouse) 381990
