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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB5 was identified though sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. Further experiments indicated that it binds DNA and can directly repress transcription of the cell cycle arrest gene p21. ZBTB5 can also interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: expressed in brain and neural tube; KIAA0354; RP11-397D12.5; transcription factor ZNF-POZ; unnamed protein product
基因别名: 5930421I10; 9430083K24Rik; mKIAA0354
UniProt ID: (Human) O15062, (Mouse) Q7TQG0
Entrez Gene ID: (Human) 9925, (Mouse) 230119, (Rat) 298084